Game Frame 2 uses APA102C LEDs (Adafruit calls them DotStar). Unfortunately NeoPixels are not compatible with the IR receiver since they tie up the system interrupts in order to meet their exact timing.
That said, you should be able to get it working with NeoPixels at the expense of the IR working properly. Look for a FastLED example using WS2812 to see the syntax on how to init them.